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Assay Detail

CHEMBL3875644

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant FT (unknown origin) using FPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies.
Mansha M, Kumari UU, Cournia Z, Ullah N.
Eur J Med Chem (2016) 124 : 666 -676
PubMed 27620969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.96 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL135561 1 5.96
CHEMBL3885040 1 -
CHEMBL3885188 1 -
CHEMBL3885443 1 -
CHEMBL3884872 1 -
CHEMBL3884658 1 -
CHEMBL3883400 1 -
CHEMBL3884852 1 -
CHEMBL3883522 1 -
CHEMBL3885260 1 -
CHEMBL3883795 1 -
CHEMBL3884603 1 -
CHEMBL3883981 1 -
CHEMBL3884346 1 -
CHEMBL3884083 1 -
CHEMBL3884826 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL135561 IC50 = 1100.0 nM 5.96
CHEMBL3885040 IC50 > 100000.0 nM -
CHEMBL3885188 IC50 > 100000.0 nM -
CHEMBL3885443 IC50 > 100000.0 nM -
CHEMBL3884872 IC50 > 100000.0 nM -
CHEMBL3884658 IC50 > 100000.0 nM -
CHEMBL3883400 IC50 > 100000.0 nM -
CHEMBL3884852 IC50 > 100000.0 nM -
CHEMBL3883522 IC50 > 100000.0 nM -
CHEMBL3885260 IC50 > 100000.0 nM -
CHEMBL3883795 IC50 > 100000.0 nM -
CHEMBL3884603 IC50 > 100000.0 nM -
CHEMBL3883981 IC50 > 100000.0 nM -
CHEMBL3884346 IC50 > 100000.0 nM -
CHEMBL3884083 IC50 > 100000.0 nM -
CHEMBL3884826 IC50 > 100000.0 nM -