Assay Detail
ADMET
CHEMBL3875679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum incubated for 60 mins by liquid scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.90 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885471 | — | — | 1 | 7.78 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.37 |
| CHEMBL3884325 | — | — | 1 | 6.94 |
| CHEMBL3884161 | — | — | 1 | 6.73 |
| CHEMBL3883955 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885471 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL85 | RISPERIDONE | Ki | = | 42.6 | nM | 7.37 |
| CHEMBL3884325 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL3884161 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL3883955 | — | Ki | = | 1998.0 | nM | 5.70 |