Assay Detail
Functional
CHEMBL3875831
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Antimalarial activity against Plasmodium falciparum 3D7 by high throughput screening assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL546789 | — | — | 1 | 8.05 |
| CHEMBL527864 | — | — | 1 | 7.40 |
| CHEMBL533976 | — | — | 1 | 6.86 |
| CHEMBL3885012 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL546789 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL527864 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL533976 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3885012 | — | IC50 | = | 759.0 | nM | 6.12 |