Assay Detail
Binding
CHEMBL3875980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Listeria monocytogenes C-terminal His6-tagged NADK1 expressed in Escherichia coli BL21(DE3) assessed as reduction in NADP production using varying levels of NAD as substrate by glucose-6-phosphate dehydrogenase coupled enzyme based spectrophotometric method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Listeria monocytogenes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 5.36 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884876 | — | — | 1 | 7.00 |
| CHEMBL3884652 | — | — | 1 | 6.60 |
| CHEMBL3885397 | — | — | 1 | 6.52 |
| CHEMBL3885137 | — | — | 1 | 6.40 |
| CHEMBL3883397 | — | — | 1 | 6.30 |
| CHEMBL3885310 | — | — | 1 | 6.30 |
| CHEMBL3885465 | — | — | 1 | 6.30 |
| CHEMBL3883415 | — | — | 1 | 6.12 |
| CHEMBL3884982 | — | — | 1 | 6.00 |
| CHEMBL3885356 | — | — | 1 | 5.82 |
| CHEMBL3883614 | — | — | 1 | 5.70 |
| CHEMBL3884846 | — | — | 1 | 5.70 |
| CHEMBL3883980 | — | — | 1 | 5.70 |
| CHEMBL3885076 | — | — | 1 | 5.52 |
| CHEMBL3884746 | — | — | 1 | 5.46 |
| CHEMBL3884775 | — | — | 1 | 5.30 |
| CHEMBL3885345 | — | — | 1 | 5.30 |
| CHEMBL3885227 | — | — | 1 | 5.30 |
| CHEMBL3883576 | — | — | 1 | 5.22 |
| CHEMBL3884119 | — | — | 1 | 5.19 |
| CHEMBL3883763 | — | — | 1 | 5.12 |
| CHEMBL3883922 | — | — | 1 | 5.00 |
| CHEMBL3883970 | — | — | 1 | 4.66 |
| CHEMBL3883775 | — | — | 1 | 4.64 |
| CHEMBL3884180 | — | — | 1 | 4.60 |
| CHEMBL3884857 | — | — | 1 | 4.52 |
| CHEMBL3884901 | — | — | 1 | 4.52 |
| CHEMBL3884239 | — | — | 1 | 4.52 |
| CHEMBL3885259 | — | — | 1 | 4.40 |
| CHEMBL3884544 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884876 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3884652 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3885397 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3885137 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3883397 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3885310 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3885465 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3883415 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL3884982 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3885356 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3883614 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3884846 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3883980 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3885076 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3884746 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL3885345 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3884775 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3885227 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3883576 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL3884119 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL3883763 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL3883922 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3883970 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL3883775 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL3884180 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL3884857 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL3884239 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL3884901 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL3885259 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3884544 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3885207 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL3883373 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL3884081 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL3884345 | — | Ki | = | 140000.0 | nM | - |