Assay Detail
Binding
CHEMBL3876010
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Inhibition of Escherichia coli thymidine phosphorylase expressed in Escherichia coli preincubated for 10 mins followed by thymidine substrate addition measured for 10 mins by spectrophotometric method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.35 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289117 | — | — | 1 | 4.37 |
| CHEMBL127066 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289117 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL127066 | — | IC50 | = | 46200.0 | nM | 4.33 |