Assay Detail
Binding
CHEMBL3877018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.90 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282199 | — | — | 1 | 9.15 |
| CHEMBL3884095 | — | — | 1 | 8.07 |
| CHEMBL3883640 | — | — | 1 | 7.63 |
| CHEMBL3883542 | — | — | 1 | 7.46 |
| CHEMBL3884778 | — | — | 1 | 7.35 |
| CHEMBL3884714 | — | — | 1 | 7.35 |
| CHEMBL3885389 | — | — | 1 | 7.27 |
| CHEMBL3884584 | — | — | 1 | 7.02 |
| CHEMBL3885319 | — | — | 1 | 6.84 |
| CHEMBL3883995 | — | — | 1 | 6.74 |
| CHEMBL3883517 | — | — | 1 | 6.56 |
| CHEMBL3885178 | — | — | 1 | 6.49 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.41 |
| CHEMBL3884137 | — | — | 1 | 6.21 |
| CHEMBL3884743 | — | — | 1 | 6.00 |
| CHEMBL3884728 | — | — | 1 | 5.88 |
| CHEMBL3884634 | — | — | 1 | 5.88 |
| CHEMBL3885282 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282199 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL3884095 | — | Ki | = | 8.42 | nM | 8.07 |
| CHEMBL3883640 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL3883542 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL3884778 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL3884714 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL3885389 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL3884584 | — | Ki | = | 94.7 | nM | 7.02 |
| CHEMBL3885319 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL3883995 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL3883517 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL3885178 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL3884137 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL3884743 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL3884728 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL3884634 | — | Ki | = | 1328.0 | nM | 5.88 |
| CHEMBL3885282 | — | Ki | = | 1377.0 | nM | 5.86 |