Assay Detail
Binding
CHEMBL3877052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant C-terminal His-tagged human LTA4H aminopeptidase activity expressed in Escherichia coli using L-alanine-4-nitro-anilide hydrochloride as substrate preincubated for 20 mins followed by substrate addition
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.82 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884665 | — | — | 1 | 5.52 |
| CHEMBL3884622 | — | — | 1 | 5.31 |
| CHEMBL3883608 | — | — | 1 | 5.12 |
| CHEMBL3884753 | — | — | 1 | 5.03 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 5.00 |
| CHEMBL25948 | SHOGAOL | — | 1 | 4.90 |
| CHEMBL3883497 | — | — | 1 | 4.67 |
| CHEMBL3884773 | — | — | 1 | 4.66 |
| CHEMBL3883635 | — | — | 1 | 4.34 |
| CHEMBL3885075 | — | — | 1 | 4.25 |
| CHEMBL1950582 | — | — | 1 | 4.25 |
| CHEMBL3883516 | — | — | 1 | - |
| CHEMBL3883439 | — | — | 1 | - |
| CHEMBL3884952 | — | — | 1 | - |
| CHEMBL3884745 | — | — | 1 | - |
| CHEMBL3884202 | — | — | 1 | - |
| CHEMBL3526544 | — | — | 1 | - |
| CHEMBL3885118 | — | — | 1 | - |
| CHEMBL3884151 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884665 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL3884622 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL3883608 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL3884753 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL25948 | SHOGAOL | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL3883497 | — | IC50 | = | 21590.0 | nM | 4.67 |
| CHEMBL3884773 | — | IC50 | = | 22110.0 | nM | 4.66 |
| CHEMBL3883635 | — | IC50 | = | 45610.0 | nM | 4.34 |
| CHEMBL3885075 | — | IC50 | = | 56270.0 | nM | 4.25 |
| CHEMBL1950582 | — | IC50 | = | 56120.0 | nM | 4.25 |
| CHEMBL3883516 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3526544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3885118 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884151 | — | IC50 | > | 100000.0 | nM | - |