Assay Detail
Binding
CHEMBL3877053
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Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 production using LTA4 as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by enzyme immunoassay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.58 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884665 | — | — | 1 | 5.14 |
| CHEMBL3884622 | — | — | 1 | 4.95 |
| CHEMBL3883608 | — | — | 1 | 4.91 |
| CHEMBL3883497 | — | — | 1 | 4.82 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 4.74 |
| CHEMBL25948 | SHOGAOL | — | 1 | 4.61 |
| CHEMBL3884773 | — | — | 1 | 4.56 |
| CHEMBL3884753 | — | — | 1 | 4.53 |
| CHEMBL1950582 | — | — | 1 | 4.23 |
| CHEMBL3885075 | — | — | 1 | 4.18 |
| CHEMBL3883635 | — | — | 1 | 4.17 |
| CHEMBL3884151 | — | — | 1 | 4.11 |
| CHEMBL3883516 | — | — | 1 | - |
| CHEMBL3883439 | — | — | 1 | - |
| CHEMBL3884952 | — | — | 1 | - |
| CHEMBL3884745 | — | — | 1 | - |
| CHEMBL3884202 | — | — | 1 | - |
| CHEMBL3526544 | — | — | 1 | - |
| CHEMBL3885118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884665 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL3884622 | — | IC50 | = | 11270.0 | nM | 4.95 |
| CHEMBL3883608 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3883497 | — | IC50 | = | 15240.0 | nM | 4.82 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 18010.0 | nM | 4.74 |
| CHEMBL25948 | SHOGAOL | IC50 | = | 24610.0 | nM | 4.61 |
| CHEMBL3884773 | — | IC50 | = | 27620.0 | nM | 4.56 |
| CHEMBL3884753 | — | IC50 | = | 29470.0 | nM | 4.53 |
| CHEMBL1950582 | — | IC50 | = | 58290.0 | nM | 4.23 |
| CHEMBL3885075 | — | IC50 | = | 66430.0 | nM | 4.18 |
| CHEMBL3883635 | — | IC50 | = | 67120.0 | nM | 4.17 |
| CHEMBL3884151 | — | IC50 | = | 77820.0 | nM | 4.11 |
| CHEMBL3883516 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3526544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3885118 | — | IC50 | > | 100000.0 | nM | - |