Assay Detail
Binding
CHEMBL3877071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-betaA-DIIRNIARHLAQVGDSMRSI-NH2 binding to recombinant human Bcl2A1 (1 to 152 residues) BH3 binding site expressed in Escherichia coli measured after 2 hrs by fluorescence polarization assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.50 | 7.50 |
| IC50 | 2 | 7.52 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883565 | — | — | 2 | 8.07 |
| CHEMBL3884841 | — | — | 2 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883565 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3884841 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3884841 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3883565 | — | Ki | < | 0.1 | nM | - |