Assay Detail
ADMET
CHEMBL3877547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from rat alpha3beta4 nAChR by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.24 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389964 | — | — | 1 | 7.19 |
| CHEMBL71085 | — | — | 1 | 6.44 |
| CHEMBL3970672 | — | — | 1 | 5.09 |
| CHEMBL3948977 | — | — | 1 | - |
| CHEMBL3898434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389964 | — | Ki | = | 64.6 | nM | 7.19 |
| CHEMBL71085 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL3970672 | — | Ki | = | 8098.0 | nM | 5.09 |
| CHEMBL3948977 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3898434 | — | Ki | > | 10000.0 | nM | - |