Assay Detail
Binding
CHEMBL3877885
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Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEKT |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.44 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.52 |
| CHEMBL3982215 | — | — | 1 | 7.51 |
| CHEMBL3961827 | — | — | 1 | 6.97 |
| CHEMBL3975220 | — | — | 1 | 6.88 |
| CHEMBL3954556 | — | — | 1 | 6.76 |
| CHEMBL3976659 | — | — | 1 | 6.71 |
| CHEMBL3966718 | — | — | 1 | 6.71 |
| CHEMBL3921278 | — | — | 1 | 6.43 |
| CHEMBL3936976 | — | — | 1 | 6.35 |
| CHEMBL3945691 | — | — | 1 | 6.14 |
| CHEMBL3894329 | — | — | 1 | 5.68 |
| CHEMBL3963862 | — | — | 1 | 5.50 |
| CHEMBL3945856 | — | — | 1 | 5.49 |
| CHEMBL3964242 | — | — | 1 | 5.44 |
| CHEMBL3905947 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3982215 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3961827 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL3975220 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL3954556 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL3976659 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL3966718 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL3921278 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL3936976 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3945691 | — | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL3894329 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL3963862 | — | Ki | = | 3171.0 | nM | 5.50 |
| CHEMBL3945856 | — | Ki | = | 3213.0 | nM | 5.49 |
| CHEMBL3964242 | — | Ki | = | 3605.0 | nM | 5.44 |
| CHEMBL3905947 | — | Ki | > | 10000.0 | nM | - |