Assay Detail
Binding
CHEMBL3877889
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Antagonist activity at rhesus monkey D1 receptor expressed in HEK293 cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.50 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13668 | — | — | 1 | 8.62 |
| CHEMBL3961827 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13668 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3961827 | — | IC50 | = | 416.0 | nM | 6.38 |