Assay Detail
Binding
CHEMBL3877892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE pretreated for 20 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.79 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.25 |
| CHEMBL3962358 | — | — | 1 | 5.00 |
| CHEMBL3935090 | — | — | 1 | 4.99 |
| CHEMBL3971112 | — | — | 1 | 4.70 |
| CHEMBL3892498 | — | — | 1 | 4.35 |
| CHEMBL3900327 | — | — | 1 | 4.22 |
| CHEMBL3910836 | — | — | 1 | 4.00 |
| CHEMBL3971444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3962358 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3935090 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3971112 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3892498 | — | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL3900327 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3910836 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3971444 | — | IC50 | = | 110000.0 | nM | - |