Assay Detail
Binding
CHEMBL3878022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Electrophorus electricus acetylcholinesterase in presence of varying acetylthiocholine iodide substrate level preincubated for 20 mins followed by substrate addition measured every 1 min for 30 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.25 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3916022 | — | — | 1 | 6.28 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 6.27 |
| CHEMBL3922793 | — | — | 1 | 5.85 |
| CHEMBL3913329 | — | — | 1 | 5.81 |
| CHEMBL3941312 | — | — | 1 | 5.55 |
| CHEMBL3894580 | — | — | 1 | 5.46 |
| CHEMBL3897572 | — | — | 1 | 5.38 |
| CHEMBL3949522 | — | — | 1 | 5.36 |
| CHEMBL3957684 | — | — | 1 | 5.35 |
| CHEMBL3905115 | — | — | 1 | 5.29 |
| CHEMBL3921743 | — | — | 1 | 5.21 |
| CHEMBL3978195 | — | — | 1 | 5.21 |
| CHEMBL3959216 | — | — | 1 | 5.11 |
| CHEMBL3949066 | — | — | 1 | 5.11 |
| CHEMBL3968731 | — | — | 1 | 5.03 |
| CHEMBL3950513 | — | — | 1 | 5.03 |
| CHEMBL3975982 | — | — | 1 | 4.98 |
| CHEMBL3963893 | — | — | 1 | 4.87 |
| CHEMBL3924020 | — | — | 1 | 4.83 |
| CHEMBL3964220 | — | — | 1 | 4.83 |
| CHEMBL3947927 | — | — | 1 | 4.70 |
| CHEMBL2104722 | PICLOXYDINE | 2.0 | 1 | 4.66 |
| CHEMBL3940753 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3916022 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL3922793 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL3913329 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL3941312 | — | Ki | = | 2790.0 | nM | 5.55 |
| CHEMBL3894580 | — | Ki | = | 3430.0 | nM | 5.46 |
| CHEMBL3897572 | — | Ki | = | 4190.0 | nM | 5.38 |
| CHEMBL3949522 | — | Ki | = | 4340.0 | nM | 5.36 |
| CHEMBL3957684 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL3905115 | — | Ki | = | 5080.0 | nM | 5.29 |
| CHEMBL3921743 | — | Ki | = | 6170.0 | nM | 5.21 |
| CHEMBL3978195 | — | Ki | = | 6110.0 | nM | 5.21 |
| CHEMBL3959216 | — | Ki | = | 7740.0 | nM | 5.11 |
| CHEMBL3949066 | — | Ki | = | 7770.0 | nM | 5.11 |
| CHEMBL3968731 | — | Ki | = | 9340.0 | nM | 5.03 |
| CHEMBL3950513 | — | Ki | = | 9250.0 | nM | 5.03 |
| CHEMBL3975982 | — | Ki | = | 10410.0 | nM | 4.98 |
| CHEMBL3963893 | — | Ki | = | 13530.0 | nM | 4.87 |
| CHEMBL3924020 | — | Ki | = | 14860.0 | nM | 4.83 |
| CHEMBL3964220 | — | Ki | = | 14920.0 | nM | 4.83 |
| CHEMBL3947927 | — | Ki | = | 19830.0 | nM | 4.70 |
| CHEMBL2104722 | PICLOXYDINE | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL3940753 | — | Ki | = | 25550.0 | nM | 4.59 |