Assay Detail
Binding
CHEMBL3878023
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Non-competitive inhibition of Electrophorus electricus acetylcholinesterase in presence of varying acetylthiocholine iodide substrate level preincubated for 20 mins followed by substrate addition measured every 1 min for 30 mins
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 4.47 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3916022 | — | — | 1 | 5.53 |
| CHEMBL3949522 | — | — | 1 | 4.86 |
| CHEMBL3949066 | — | — | 1 | 4.79 |
| CHEMBL3941312 | — | — | 1 | 4.70 |
| CHEMBL3922793 | — | — | 1 | 4.66 |
| CHEMBL3921743 | — | — | 1 | 4.59 |
| CHEMBL2104722 | PICLOXYDINE | 2.0 | 1 | 4.55 |
| CHEMBL3894580 | — | — | 1 | 4.45 |
| CHEMBL3897572 | — | — | 1 | 4.39 |
| CHEMBL3959216 | — | — | 1 | 4.38 |
| CHEMBL3975982 | — | — | 1 | 4.34 |
| CHEMBL3905115 | — | — | 1 | 4.31 |
| CHEMBL3964220 | — | — | 1 | 4.23 |
| CHEMBL3947927 | — | — | 1 | 4.21 |
| CHEMBL3978195 | — | — | 1 | 4.18 |
| CHEMBL3963893 | — | — | 1 | 4.16 |
| CHEMBL3968731 | — | — | 1 | 4.12 |
| CHEMBL3940753 | — | — | 1 | 4.05 |
| CHEMBL3913329 | — | — | 1 | - |
| CHEMBL3957684 | — | — | 1 | - |
| CHEMBL3950513 | — | — | 1 | - |
| CHEMBL3924020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3916022 | — | Ki | = | 2960.0 | nM | 5.53 |
| CHEMBL3949522 | — | Ki | = | 13680.0 | nM | 4.86 |
| CHEMBL3949066 | — | Ki | = | 16190.0 | nM | 4.79 |
| CHEMBL3941312 | — | Ki | = | 19940.0 | nM | 4.70 |
| CHEMBL3922793 | — | Ki | = | 21770.0 | nM | 4.66 |
| CHEMBL3921743 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL2104722 | PICLOXYDINE | Ki | = | 28310.0 | nM | 4.55 |
| CHEMBL3894580 | — | Ki | = | 35550.0 | nM | 4.45 |
| CHEMBL3897572 | — | Ki | = | 40530.0 | nM | 4.39 |
| CHEMBL3959216 | — | Ki | = | 41210.0 | nM | 4.38 |
| CHEMBL3975982 | — | Ki | = | 45230.0 | nM | 4.34 |
| CHEMBL3905115 | — | Ki | = | 49100.0 | nM | 4.31 |
| CHEMBL3964220 | — | Ki | = | 58580.0 | nM | 4.23 |
| CHEMBL3947927 | — | Ki | = | 62240.0 | nM | 4.21 |
| CHEMBL3978195 | — | Ki | = | 66680.0 | nM | 4.18 |
| CHEMBL3963893 | — | Ki | = | 69160.0 | nM | 4.16 |
| CHEMBL3968731 | — | Ki | = | 75300.0 | nM | 4.12 |
| CHEMBL3940753 | — | Ki | = | 88860.0 | nM | 4.05 |
| CHEMBL3913329 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3957684 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3950513 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3924020 | — | Ki | = | 104270.0 | nM | - |