Assay Detail
Binding
CHEMBL3878026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from recombinant human alpha1a adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.76 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3892434 | — | — | 1 | 7.24 |
| CHEMBL2234448 | — | — | 1 | 7.04 |
| CHEMBL3938383 | — | — | 1 | 6.73 |
| CHEMBL3929328 | — | — | 1 | 6.70 |
| CHEMBL3981480 | — | — | 1 | 6.64 |
| CHEMBL3901382 | — | — | 1 | 6.57 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.41 |
| CHEMBL1183249 | — | — | 1 | - |
| CHEMBL3911497 | — | — | 1 | - |
| CHEMBL3970754 | — | — | 1 | - |
| CHEMBL3917316 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3892434 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL2234448 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL3938383 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL3929328 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL3981480 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL3901382 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL13647 | BMY-7378 | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL1183249 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3911497 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3970754 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3917316 | — | Ki | > | 1000.0 | nM | - |