Assay Detail
Binding
CHEMBL3878322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-gp in human MDA435/LCC6MDR cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 1 uM measured after 5 days by Cell Titer 96 Aqueous assay (Rvb = 139.3 +/- 7.5 nM)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Extending the structure-activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.51 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.74 |
| CHEMBL3967698 | — | — | 1 | 8.54 |
| CHEMBL3965480 | — | — | 1 | 8.20 |
| CHEMBL3924025 | — | — | 1 | 7.93 |
| CHEMBL3963514 | — | — | 1 | 7.91 |
| CHEMBL3921424 | — | — | 1 | 7.83 |
| CHEMBL3910169 | — | — | 1 | 7.80 |
| CHEMBL3931842 | — | — | 1 | 7.79 |
| CHEMBL3896017 | — | — | 1 | 7.71 |
| CHEMBL3947351 | — | — | 1 | 7.63 |
| CHEMBL3968218 | — | — | 1 | 7.57 |
| CHEMBL3956801 | — | — | 1 | 7.50 |
| CHEMBL3893405 | — | — | 1 | 7.48 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.46 |
| CHEMBL3919559 | — | — | 1 | 7.40 |
| CHEMBL3912467 | — | — | 1 | 7.39 |
| CHEMBL3982377 | — | — | 1 | 7.33 |
| CHEMBL3931079 | — | — | 1 | 7.28 |
| CHEMBL3929244 | — | — | 1 | 7.27 |
| CHEMBL3983680 | — | — | 1 | 7.16 |
| CHEMBL3955037 | — | — | 1 | 7.01 |
| CHEMBL3903775 | — | — | 1 | 7.01 |
| CHEMBL3905000 | — | — | 1 | 6.99 |
| CHEMBL3919555 | — | — | 1 | 6.99 |
| CHEMBL1308480 | — | — | 1 | 6.96 |
| CHEMBL3408773 | — | — | 1 | 6.95 |
| CHEMBL3894852 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3967698 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3965480 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3924025 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL3963514 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL3921424 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL3910169 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3931842 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL3896017 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL3947351 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL3968218 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL3956801 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL3893405 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL3919559 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL3912467 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL3982377 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL3931079 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3929244 | — | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL3983680 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL3955037 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3903775 | — | IC50 | = | 98.6 | nM | 7.01 |
| CHEMBL3905000 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3919555 | — | IC50 | = | 101.7 | nM | 6.99 |
| CHEMBL1308480 | — | IC50 | = | 110.2 | nM | 6.96 |
| CHEMBL3408773 | — | IC50 | = | 111.5 | nM | 6.95 |
| CHEMBL3894852 | — | IC50 | = | 129.0 | nM | 6.89 |