Assay Detail
Binding
CHEMBL3878326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-gp in human MDA435/LCC6MDR cells assessed as reduction of doxorubicin cytotoxic IC50 by half after 5 days by Cell Titer 96 Aqueous assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Extending the structure-activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.77 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3967698 | — | — | 1 | 6.92 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3967698 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 245.0 | nM | 6.61 |