Assay Detail
Binding
CHEMBL3878378
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Inhibition of Dengue virus 3 NS5 2'-O-MTase activity assessed as reduction in [3H]AdoMet transfer to 7MeGpppAC4 capped RNA substrate after 30 mins by microbeta liquid scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 2.67 | 4.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3899268 | — | — | 1 | 4.04 |
| CHEMBL3934153 | — | — | 1 | 2.55 |
| CHEMBL1236744 | — | — | 1 | 2.05 |
| CHEMBL3237625 | — | — | 1 | 2.03 |
| CHEMBL3941938 | — | — | 1 | - |
| CHEMBL3971531 | — | — | 1 | - |
| CHEMBL3976785 | — | — | 1 | - |
| CHEMBL3959384 | — | — | 1 | - |
| CHEMBL3890313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3899268 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL3934153 | — | IC50 | = | 2800000.0 | nM | 2.55 |
| CHEMBL1236744 | — | IC50 | = | 9000000.0 | nM | 2.05 |
| CHEMBL3237625 | — | IC50 | = | 9300000.0 | nM | 2.03 |
| CHEMBL3941938 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL3971531 | — | IC50 | = | 368000.0 | nM | - |
| CHEMBL3976785 | — | IC50 | = | 435000.0 | nM | - |
| CHEMBL3959384 | — | IC50 | = | 369000.0 | nM | - |
| CHEMBL3890313 | — | IC50 | = | 452000.0 | nM | - |