Assay Detail
Binding
CHEMBL3878510
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Inhibition of Trypanosoma brucei methionyl tRNA synthetase preincubated for 15 mins followed by L-methionine substrate addition measured after 120 mins by ATP- depletion chemiluminescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.44 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973685 | — | — | 1 | 7.22 |
| CHEMBL3940296 | — | — | 1 | 7.07 |
| CHEMBL3902001 | — | — | 1 | 6.97 |
| CHEMBL3920674 | — | — | 1 | 6.91 |
| CHEMBL3942072 | — | — | 1 | 6.86 |
| CHEMBL3952954 | — | — | 1 | 6.74 |
| CHEMBL3893388 | — | — | 1 | 6.72 |
| CHEMBL3982361 | — | — | 1 | 6.71 |
| CHEMBL3957698 | — | — | 1 | 6.61 |
| CHEMBL3944785 | — | — | 1 | 6.54 |
| CHEMBL3926341 | — | — | 1 | 6.24 |
| CHEMBL3982490 | — | — | 1 | 6.17 |
| CHEMBL3930540 | — | — | 1 | 6.16 |
| CHEMBL3970772 | — | — | 1 | 6.09 |
| CHEMBL3919401 | — | — | 1 | 6.03 |
| CHEMBL3968743 | — | — | 1 | 5.98 |
| CHEMBL3893578 | — | — | 1 | 5.66 |
| CHEMBL3965873 | — | — | 1 | 5.30 |
| CHEMBL3963464 | — | — | 1 | - |
| CHEMBL3974359 | — | — | 1 | - |
| CHEMBL3935989 | — | — | 1 | - |
| CHEMBL3953659 | — | — | 1 | - |
| CHEMBL3964014 | — | — | 1 | - |
| CHEMBL3962406 | — | — | 1 | - |
| CHEMBL3937165 | — | — | 1 | - |
| CHEMBL3938391 | — | — | 1 | - |
| CHEMBL3969840 | — | — | 1 | - |
| CHEMBL3925534 | — | — | 1 | - |
| CHEMBL3978033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973685 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3940296 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3902001 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL3920674 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3942072 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3952954 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3893388 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3982361 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3957698 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL3944785 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL3926341 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3982490 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL3930540 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL3970772 | — | IC50 | = | 812.0 | nM | 6.09 |
| CHEMBL3919401 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL3968743 | — | IC50 | = | 1054.0 | nM | 5.98 |
| CHEMBL3893578 | — | IC50 | = | 2166.0 | nM | 5.66 |
| CHEMBL3965873 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL3963464 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3974359 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3935989 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3953659 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3964014 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3962406 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3937165 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3938391 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3969840 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3925534 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL3978033 | — | IC50 | < | 50.0 | nM | - |