Assay Detail
Binding
CHEMBL3878758
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Inhibition of TSPO (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.93 | 9.04 |
| Ki | 2 | 8.53 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205767 | — | — | 1 | 9.04 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.96 |
| CHEMBL3970955 | — | — | 1 | 8.80 |
| CHEMBL180523 | — | — | 1 | 8.57 |
| CHEMBL63154 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205767 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL481537 | PK-11195 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3970955 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL180523 | — | Ki | = | 2.68 | nM | 8.57 |
| CHEMBL63154 | — | Ki | = | 3.25 | nM | 8.49 |