Assay Detail
Binding
CHEMBL3879169
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Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay
12
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.87 | 9.20 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3895863 | — | — | 2 | 9.20 |
| CHEMBL3897587 | — | — | 2 | 8.70 |
| CHEMBL3913807 | — | — | 2 | 8.70 |
| CHEMBL3906477 | — | — | 1 | 8.10 |
| CHEMBL3967137 | — | — | 2 | 7.10 |
| CHEMBL3922787 | — | — | 2 | 7.10 |
| CHEMBL3934441 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3895863 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL3897587 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3913807 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3906477 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3967137 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3922787 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3934441 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3895863 | — | Inhibition | - | % | - | |
| CHEMBL3967137 | — | Inhibition | - | % | - | |
| CHEMBL3922787 | — | Inhibition | - | % | - | |
| CHEMBL3897587 | — | Inhibition | - | % | - | |
| CHEMBL3913807 | — | Inhibition | - | % | - |