Assay Detail
Binding
CHEMBL3879977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKK2 (unknown origin) using pSer36-IkappaB peptide as substrate preincubated for 30 mins followed by substrate and 50 uM ATP addition measured after 45 mins by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substantially pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic acid as an IkB kinase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.76 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3897289 | — | — | 1 | 9.40 |
| CHEMBL3915686 | — | — | 1 | 9.10 |
| CHEMBL3949606 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3897289 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3915686 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3949606 | — | IC50 | = | 16.8 | nM | 7.78 |