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Assay Detail

CHEMBL3880089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant HPTPbeta (unknown origin) preincubated for 10 mins followed by substrate addition measured after 15 mins by DiFMUP probe-based fluorescence assay
ChEMBL ↗
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Receptor-type tyrosine-protein phosphatase beta (CHEMBL2706) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Compositions and methods for treating ocular edema, neovascularization and related diseases
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 98 8.28 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3928885 — — 1 11.00
CHEMBL3948990 — — 1 10.10
CHEMBL3935358 — — 1 10.10
CHEMBL3963181 — — 1 10.05
CHEMBL3967271 — — 1 10.00
CHEMBL3962687 — — 1 10.00
CHEMBL3907615 — — 1 10.00
CHEMBL3945835 — — 1 9.85
CHEMBL3921571 — — 1 9.80
CHEMBL3891215 — — 1 9.79
CHEMBL3956877 — — 1 9.70
CHEMBL3966138 — — 1 9.70
CHEMBL3946325 — — 1 9.70
CHEMBL3900884 — — 1 9.70
CHEMBL3924295 — — 1 9.70
CHEMBL3973378 — — 1 9.62
CHEMBL3981985 — — 1 9.52
CHEMBL3984069 — — 1 9.52
CHEMBL3974482 — — 1 9.52
CHEMBL3953372 — — 1 9.52
CHEMBL3975815 — — 1 9.52
CHEMBL3898194 — — 1 9.52
CHEMBL3930153 — — 1 9.40
CHEMBL3974146 — — 1 9.40
CHEMBL3906794 — — 1 9.22
CHEMBL3911161 — — 1 9.00
CHEMBL3918500 — — 1 9.00
CHEMBL3903926 — — 1 9.00
CHEMBL3951495 — — 1 9.00
CHEMBL3922081 — — 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3928885 — IC50 = 0.01 nM 11.00
CHEMBL3948990 — IC50 = 0.08 nM 10.10
CHEMBL3935358 — IC50 = 0.08 nM 10.10
CHEMBL3963181 — IC50 = 0.09 nM 10.05
CHEMBL3967271 — IC50 = 0.1 nM 10.00
CHEMBL3962687 — IC50 = 0.1 nM 10.00
CHEMBL3907615 — IC50 = 0.1 nM 10.00
CHEMBL3945835 — IC50 = 0.14 nM 9.85
CHEMBL3921571 — IC50 = 0.157 nM 9.80
CHEMBL3891215 — IC50 = 0.162 nM 9.79
CHEMBL3924295 — IC50 = 0.2 nM 9.70
CHEMBL3900884 — IC50 = 0.2 nM 9.70
CHEMBL3966138 — IC50 = 0.2 nM 9.70
CHEMBL3956877 — IC50 = 0.2 nM 9.70
CHEMBL3946325 — IC50 = 0.2 nM 9.70
CHEMBL3973378 — IC50 = 0.24 nM 9.62
CHEMBL3975815 — IC50 = 0.3 nM 9.52
CHEMBL3898194 — IC50 = 0.3 nM 9.52
CHEMBL3953372 — IC50 = 0.3 nM 9.52
CHEMBL3974482 — IC50 = 0.3 nM 9.52
CHEMBL3984069 — IC50 = 0.3 nM 9.52
CHEMBL3981985 — IC50 = 0.3 nM 9.52
CHEMBL3930153 — IC50 = 0.4 nM 9.40
CHEMBL3974146 — IC50 = 0.4 nM 9.40
CHEMBL3906794 — IC50 = 0.6 nM 9.22
CHEMBL3911161 — IC50 = 1.0 nM 9.00
CHEMBL3904860 — IC50 = 1.0 nM 9.00
CHEMBL3903349 — IC50 = 1.0 nM 9.00
CHEMBL3922081 — IC50 = 1.0 nM 9.00
CHEMBL3903926 — IC50 = 1.0 nM 9.00
CHEMBL3918500 — IC50 = 1.0 nM 9.00
CHEMBL3951495 — IC50 = 1.0 nM 9.00
CHEMBL3900100 — IC50 = 2.0 nM 8.70
CHEMBL3902862 — IC50 = 2.0 nM 8.70
CHEMBL3984666 — IC50 = 2.0 nM 8.70
CHEMBL3979222 — IC50 = 2.0 nM 8.70
CHEMBL3977448 — IC50 = 2.0 nM 8.70
CHEMBL3986182 — IC50 = 3.0 nM 8.52
CHEMBL3961813 — IC50 = 3.0 nM 8.52
CHEMBL3908489 — IC50 = 3.0 nM 8.52
CHEMBL3957692 — IC50 = 3.0 nM 8.52
CHEMBL3968193 — IC50 = 4.0 nM 8.40
CHEMBL3922889 — IC50 = 6.0 nM 8.22
CHEMBL3959492 — IC50 = 6.0 nM 8.22
CHEMBL3947747 — IC50 = 6.0 nM 8.22
CHEMBL3981640 — IC50 = 8.0 nM 8.10
CHEMBL3938191 — IC50 = 10.0 nM 8.00
CHEMBL3975338 — IC50 = 12.0 nM 7.92
CHEMBL3933309 — IC50 = 14.0 nM 7.85
CHEMBL3960385 — IC50 = 20.0 nM 7.70