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Assay Detail

CHEMBL3880109

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type C6
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuromedin-B receptor (CHEMBL4440) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Gastrin releasing peptide compounds
(2011)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 8.27 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3890803 — — 1 10.15
CHEMBL3944194 — — 1 9.80
CHEMBL3952732 — — 1 9.70
CHEMBL3983862 — — 1 9.52
CHEMBL403317 — — 1 9.15
CHEMBL3951222 — — 1 9.10
CHEMBL3974709 — — 1 9.05
CHEMBL3953912 — — 1 8.92
CHEMBL3960359 — — 1 8.92
CHEMBL3971676 — — 1 8.89
CHEMBL3904706 — — 1 8.82
CHEMBL3953323 — — 1 8.82
CHEMBL3941990 — — 1 8.80
CHEMBL3889538 — — 1 8.77
CHEMBL3900523 — — 1 8.74
CHEMBL3907272 — — 1 8.70
CHEMBL3910471 — — 1 8.66
CHEMBL3904512 — — 1 8.66
CHEMBL3978233 — — 1 8.64
CHEMBL3934601 — — 1 8.59
CHEMBL3894747 — — 1 8.57
CHEMBL3979188 — — 1 8.51
CHEMBL3941920 — — 1 8.48
CHEMBL3903246 — — 1 8.47
CHEMBL3967904 — — 1 8.47
CHEMBL3962308 — — 1 8.42
CHEMBL3932563 — — 1 8.28
CHEMBL3923123 — — 1 8.19
CHEMBL3951758 — — 1 8.17
CHEMBL3982939 — — 1 8.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3890803 — IC50 = 0.07 nM 10.15
CHEMBL3944194 — IC50 = 0.16 nM 9.80
CHEMBL3952732 — IC50 = 0.2 nM 9.70
CHEMBL3983862 — IC50 = 0.3 nM 9.52
CHEMBL403317 — IC50 = 0.7 nM 9.15
CHEMBL3951222 — IC50 = 0.8 nM 9.10
CHEMBL3974709 — IC50 = 0.9 nM 9.05
CHEMBL3953912 — IC50 = 1.2 nM 8.92
CHEMBL3960359 — IC50 = 1.2 nM 8.92
CHEMBL3971676 — IC50 = 1.3 nM 8.89
CHEMBL3904706 — IC50 = 1.5 nM 8.82
CHEMBL3953323 — IC50 = 1.5 nM 8.82
CHEMBL3941990 — IC50 = 1.6 nM 8.80
CHEMBL3889538 — IC50 = 1.7 nM 8.77
CHEMBL3900523 — IC50 = 1.8 nM 8.74
CHEMBL3907272 — IC50 = 2.0 nM 8.70
CHEMBL3910471 — IC50 = 2.2 nM 8.66
CHEMBL3904512 — IC50 = 2.2 nM 8.66
CHEMBL3978233 — IC50 = 2.3 nM 8.64
CHEMBL3934601 — IC50 = 2.6 nM 8.59
CHEMBL3894747 — IC50 = 2.7 nM 8.57
CHEMBL3979188 — IC50 = 3.1 nM 8.51
CHEMBL3941920 — IC50 = 3.3 nM 8.48
CHEMBL3903246 — IC50 = 3.4 nM 8.47
CHEMBL3967904 — IC50 = 3.36 nM 8.47
CHEMBL3962308 — IC50 = 3.8 nM 8.42
CHEMBL3932563 — IC50 = 5.2 nM 8.28
CHEMBL3923123 — IC50 = 6.4 nM 8.19
CHEMBL3951758 — IC50 = 6.8 nM 8.17
CHEMBL3982939 — IC50 = 7.9 nM 8.10
CHEMBL3891981 — IC50 = 9.9 nM 8.00
CHEMBL3974250 — IC50 = 10.4 nM 7.98
CHEMBL3947283 — IC50 = 12.1 nM 7.92
CHEMBL3906914 — IC50 = 13.0 nM 7.89
CHEMBL3939368 — IC50 = 14.0 nM 7.85
CHEMBL3963362 — IC50 = 15.1 nM 7.82
CHEMBL3976771 — IC50 = 18.9 nM 7.72
CHEMBL3970735 — IC50 = 20.2 nM 7.70
CHEMBL3946856 — IC50 = 24.1 nM 7.62
CHEMBL3914573 — IC50 = 33.0 nM 7.48
CHEMBL3944228 — IC50 = 60.0 nM 7.22
CHEMBL3982672 — IC50 = 66.5 nM 7.18
CHEMBL3929807 — IC50 = 77.0 nM 7.11
CHEMBL3954412 — IC50 = 89.9 nM 7.05
CHEMBL3980433 — IC50 = 114.0 nM 6.94
CHEMBL3963000 — IC50 = 161.0 nM 6.79
CHEMBL3894546 — IC50 = 210.9 nM 6.68
CHEMBL3901298 — IC50 = 754.0 nM 6.12
CHEMBL3942065 — IC50 > 250.0 nM -
CHEMBL3904006 — IC50 > 800.0 nM -