Assay Detail
Binding
CHEMBL3880171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NaV channel in rat DRG neurons under holding potential at -60 mV by patch clamp method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated sodium channel (CHEMBL3988641) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Bicyclic derivatives as modulators of voltage gated ion channels
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3931977 | — | — | 1 | 5.30 |
| CHEMBL3890550 | — | — | 1 | 5.30 |
| CHEMBL3984416 | — | — | 1 | 5.30 |
| CHEMBL3949876 | — | — | 1 | 5.30 |
| CHEMBL3953036 | — | — | 1 | 5.30 |
| CHEMBL3976615 | — | — | 1 | 5.30 |
| CHEMBL3952545 | — | — | 1 | 5.30 |
| CHEMBL3957374 | — | — | 1 | - |
| CHEMBL3900363 | — | — | 1 | - |
| CHEMBL3949393 | — | — | 1 | - |
| CHEMBL3890289 | — | — | 1 | - |
| CHEMBL3935619 | — | — | 1 | - |
| CHEMBL3937475 | — | — | 1 | - |
| CHEMBL3981916 | — | — | 1 | - |
| CHEMBL3934729 | — | — | 1 | - |
| CHEMBL3934711 | — | — | 1 | - |
| CHEMBL3950333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3931977 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3890550 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3984416 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3949876 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3953036 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3976615 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3952545 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3957374 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL3900363 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3949393 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL3890289 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL3935619 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL3937475 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3981916 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3934729 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3934711 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3950333 | — | IC50 | < | 5000.0 | nM | - |