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Assay Detail

CHEMBL3880183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human S1P1 expressed in CRE-bla CHOK1 cells assessed as inhibition of forskolin-induced cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL ↗
253
Total Activities
253
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sphingosine 1-phosphate receptor 1 (CHEMBL4333) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 253 9.85 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3972549 — — 1 10.30
CHEMBL3945226 — — 1 10.30
CHEMBL3952253 — — 1 10.30
CHEMBL3920863 — — 1 10.30
CHEMBL3894084 — — 1 10.30
CHEMBL3924318 — — 1 10.30
CHEMBL3907543 — — 1 10.30
CHEMBL3957449 — — 1 10.30
CHEMBL3960138 — — 1 10.30
CHEMBL3919920 — — 1 10.30
CHEMBL3922629 — — 1 10.30
CHEMBL3915065 — — 1 10.30
CHEMBL3969165 — — 1 10.30
CHEMBL3907353 — — 1 10.30
CHEMBL3930528 — — 1 10.30
CHEMBL3926787 — — 1 10.30
CHEMBL3975029 — — 1 10.30
CHEMBL3918031 — — 1 10.30
CHEMBL3895822 — — 1 10.30
CHEMBL3940245 — — 1 10.30
CHEMBL3939008 — — 1 10.30
CHEMBL3979740 — — 1 10.30
CHEMBL3970830 — — 1 10.30
CHEMBL3916821 — — 1 10.30
CHEMBL3954097 — — 1 10.30
CHEMBL3926299 — — 1 10.30
CHEMBL3944842 — — 1 10.30
CHEMBL3984513 — — 1 10.30
CHEMBL3896496 — — 1 10.30
CHEMBL3924073 — — 1 10.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3927322 — EC50 = 0.05 nM 10.30
CHEMBL3930042 — EC50 = 0.05 nM 10.30
CHEMBL3943755 — EC50 = 0.05 nM 10.30
CHEMBL3957713 — EC50 = 0.05 nM 10.30
CHEMBL3979815 — EC50 = 0.05 nM 10.30
CHEMBL3895901 — EC50 = 0.05 nM 10.30
CHEMBL3897106 — EC50 = 0.05 nM 10.30
CHEMBL3905765 — EC50 = 0.05 nM 10.30
CHEMBL3891354 — EC50 = 0.05 nM 10.30
CHEMBL3934482 — EC50 = 0.05 nM 10.30
CHEMBL3931785 — EC50 = 0.05 nM 10.30
CHEMBL3906427 — EC50 = 0.05 nM 10.30
CHEMBL3941756 — EC50 = 0.05 nM 10.30
CHEMBL3934530 — EC50 = 0.05 nM 10.30
CHEMBL3918503 — EC50 = 0.05 nM 10.30
CHEMBL3964002 — EC50 = 0.05 nM 10.30
CHEMBL3899733 — EC50 = 0.05 nM 10.30
CHEMBL3920889 — EC50 = 0.05 nM 10.30
CHEMBL3918159 — EC50 = 0.05 nM 10.30
CHEMBL3902406 — EC50 = 0.05 nM 10.30
CHEMBL3965441 — EC50 = 0.05 nM 10.30
CHEMBL3926586 — EC50 = 0.05 nM 10.30
CHEMBL3967098 — EC50 = 0.05 nM 10.30
CHEMBL3969712 — EC50 = 0.05 nM 10.30
CHEMBL3985742 — EC50 = 0.05 nM 10.30
CHEMBL3920863 — EC50 = 0.05 nM 10.30
CHEMBL3940511 — EC50 = 0.05 nM 10.30
CHEMBL3937763 — EC50 = 0.05 nM 10.30
CHEMBL3976048 — EC50 = 0.05 nM 10.30
CHEMBL3970705 — EC50 = 0.05 nM 10.30
CHEMBL3912931 — EC50 = 0.05 nM 10.30
CHEMBL3924318 — EC50 = 0.05 nM 10.30
CHEMBL3954350 — EC50 = 0.05 nM 10.30
CHEMBL3894716 — EC50 = 0.05 nM 10.30
CHEMBL3971646 — EC50 = 0.05 nM 10.30
CHEMBL3968024 — EC50 = 0.05 nM 10.30
CHEMBL3918328 — EC50 = 0.05 nM 10.30
CHEMBL3894084 — EC50 = 0.05 nM 10.30
CHEMBL3924832 — EC50 = 0.05 nM 10.30
CHEMBL3949785 — EC50 = 0.05 nM 10.30
CHEMBL3964817 — EC50 = 0.05 nM 10.30
CHEMBL3952253 — EC50 = 0.05 nM 10.30
CHEMBL3945226 — EC50 = 0.05 nM 10.30
CHEMBL3963066 — EC50 = 0.05 nM 10.30
CHEMBL3987097 — EC50 = 0.05 nM 10.30
CHEMBL3978076 — EC50 = 0.05 nM 10.30
CHEMBL3987033 — EC50 = 0.05 nM 10.30
CHEMBL3947411 — EC50 = 0.05 nM 10.30
CHEMBL3967100 — EC50 = 0.05 nM 10.30
CHEMBL3919810 — EC50 = 0.05 nM 10.30