Assay Detail
Functional
CHEMBL3880187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.37 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3902160 | — | — | 1 | 5.97 |
| CHEMBL3894716 | — | — | 1 | 5.80 |
| CHEMBL3919445 | — | — | 1 | 5.26 |
| CHEMBL3951270 | — | — | 1 | 5.25 |
| CHEMBL3921214 | — | — | 1 | 5.18 |
| CHEMBL3899384 | — | — | 1 | 5.11 |
| CHEMBL3707247 | OZANIMOD | 4.0 | 1 | 5.02 |
| CHEMBL3922998 | — | — | 1 | - |
| CHEMBL3933952 | — | — | 1 | - |
| CHEMBL3931243 | — | — | 1 | - |
| CHEMBL3895230 | — | — | 1 | - |
| CHEMBL3910269 | — | — | 1 | - |
| CHEMBL3893172 | — | — | 1 | - |
| CHEMBL3922179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3902160 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3894716 | — | EC50 | = | 1569.0 | nM | 5.80 |
| CHEMBL3919445 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3951270 | — | EC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL3921214 | — | EC50 | = | 6662.0 | nM | 5.18 |
| CHEMBL3899384 | — | EC50 | = | 7717.0 | nM | 5.11 |
| CHEMBL3707247 | OZANIMOD | EC50 | = | 9559.0 | nM | 5.02 |
| CHEMBL3922998 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3933952 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3931243 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3895230 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3910269 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3893172 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3922179 | — | EC50 | > | 1000.0 | nM | - |