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Assay Detail

CHEMBL3880198

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method
ChEMBL ↗
364
Total Activities
364
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Methods of using macrocyclic modulators of the ghrelin receptor
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 363 7.56 10.00
%max 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3934367 — — 1 10.00
CHEMBL1923637 — — 1 10.00
CHEMBL3984338 — — 1 10.00
CHEMBL3922056 — — 1 10.00
CHEMBL1923642 — — 1 10.00
CHEMBL3907891 — — 1 10.00
CHEMBL3935670 — — 1 10.00
CHEMBL1923626 — — 1 10.00
CHEMBL3973513 — — 1 10.00
CHEMBL3918009 — — 1 10.00
CHEMBL3940705 — — 1 10.00
CHEMBL3903118 — — 1 10.00
CHEMBL3905791 — — 1 10.00
CHEMBL1923623 — — 1 10.00
CHEMBL1923625 — — 1 10.00
CHEMBL3939872 — — 1 10.00
CHEMBL3920049 — — 1 10.00
CHEMBL1923609 — — 1 10.00
CHEMBL1923610 — — 1 10.00
CHEMBL3969367 — — 1 10.00
CHEMBL3915269 — — 1 10.00
CHEMBL3918046 — — 1 10.00
CHEMBL3898794 — — 1 10.00
CHEMBL3959816 — — 1 10.00
CHEMBL3895776 — — 1 10.00
CHEMBL3893048 — — 1 10.00
CHEMBL3910300 — — 1 10.00
CHEMBL3907497 — — 1 10.00
CHEMBL3961108 — — 1 10.00
CHEMBL3913855 — — 1 10.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1923625 — Ki = 0.1 nM 10.00
CHEMBL1923626 — Ki = 0.1 nM 10.00
CHEMBL3973513 — Ki = 0.1 nM 10.00
CHEMBL3918009 — Ki = 0.1 nM 10.00
CHEMBL3940705 — Ki = 0.1 nM 10.00
CHEMBL3903118 — Ki = 0.1 nM 10.00
CHEMBL3905791 — Ki = 0.1 nM 10.00
CHEMBL1923623 — Ki = 0.1 nM 10.00
CHEMBL3922056 — Ki = 0.1 nM 10.00
CHEMBL3939872 — Ki = 0.1 nM 10.00
CHEMBL3934367 — Ki = 0.1 nM 10.00
CHEMBL3984338 — Ki = 0.1 nM 10.00
CHEMBL1923637 — Ki = 0.1 nM 10.00
CHEMBL3920049 — Ki = 0.1 nM 10.00
CHEMBL3955179 — Ki = 0.1 nM 10.00
CHEMBL3914259 — Ki = 0.1 nM 10.00
CHEMBL3955437 — Ki = 0.1 nM 10.00
CHEMBL1923609 — Ki = 0.1 nM 10.00
CHEMBL3929593 — Ki = 0.1 nM 10.00
CHEMBL3913855 — Ki = 0.1 nM 10.00
CHEMBL3961108 — Ki = 0.1 nM 10.00
CHEMBL3935670 — Ki = 0.1 nM 10.00
CHEMBL3907497 — Ki = 0.1 nM 10.00
CHEMBL3910300 — Ki = 0.1 nM 10.00
CHEMBL3893048 — Ki = 0.1 nM 10.00
CHEMBL3895776 — Ki = 0.1 nM 10.00
CHEMBL3898794 — Ki = 0.1 nM 10.00
CHEMBL3918046 — Ki = 0.1 nM 10.00
CHEMBL3915269 — Ki = 0.1 nM 10.00
CHEMBL3969367 — Ki = 0.1 nM 10.00
CHEMBL1923610 — Ki = 0.1 nM 10.00
CHEMBL3907891 — Ki = 0.1 nM 10.00
CHEMBL1923642 — Ki = 0.1 nM 10.00
CHEMBL3959816 — Ki = 0.1 nM 10.00
CHEMBL1923617 — Ki = 0.34 nM 9.47
CHEMBL1923635 — Ki = 10.0 nM 8.00
CHEMBL3942528 — Ki = 10.0 nM 8.00
CHEMBL3984464 — Ki = 10.0 nM 8.00
CHEMBL3923633 — Ki = 10.0 nM 8.00
CHEMBL3952596 — Ki = 10.0 nM 8.00
CHEMBL3912375 — Ki = 10.0 nM 8.00
CHEMBL3937200 — Ki = 10.0 nM 8.00
CHEMBL3902856 — Ki = 10.0 nM 8.00
CHEMBL3897510 — Ki = 10.0 nM 8.00
CHEMBL3900284 — Ki = 10.0 nM 8.00
CHEMBL3986628 — Ki = 10.0 nM 8.00
CHEMBL3924192 — Ki = 10.0 nM 8.00
CHEMBL1923616 — Ki = 10.0 nM 8.00
CHEMBL3953053 — Ki = 10.0 nM 8.00
CHEMBL3921499 — Ki = 10.0 nM 8.00