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Assay Detail

CHEMBL3880199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay
ChEMBL ↗
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Methods of using macrocyclic modulators of the ghrelin receptor
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 84 8.21 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1923626 — — 1 9.00
CHEMBL3918046 — — 1 9.00
CHEMBL3898794 — — 1 9.00
CHEMBL3907497 — — 1 9.00
CHEMBL3909834 — — 1 9.00
CHEMBL3946348 — — 1 9.00
CHEMBL3922056 — — 1 9.00
CHEMBL3932408 — — 1 9.00
CHEMBL1923642 — — 1 9.00
CHEMBL1923638 — — 1 9.00
CHEMBL3916659 — — 1 9.00
CHEMBL3938104 — — 1 9.00
CHEMBL3958460 — — 1 9.00
CHEMBL3973085 — — 1 9.00
CHEMBL3898348 — — 1 9.00
CHEMBL3940705 — — 1 9.00
CHEMBL3913052 — — 1 9.00
CHEMBL3905791 — — 1 9.00
CHEMBL3934402 — — 1 9.00
CHEMBL3920049 — — 1 9.00
CHEMBL1963249 ULIMORELIN 3.0 1 9.00
CHEMBL3937200 — — 1 9.00
CHEMBL3959108 — — 1 9.00
CHEMBL3889512 — — 1 9.00
CHEMBL3922810 — — 1 9.00
CHEMBL3913335 — — 1 9.00
CHEMBL3970499 — — 1 9.00
CHEMBL3913855 — — 1 9.00
CHEMBL3943086 — — 1 9.00
CHEMBL3921499 — — 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1923610 — EC50 = 1.0 nM 9.00
CHEMBL1923642 — EC50 = 1.0 nM 9.00
CHEMBL3932408 — EC50 = 1.0 nM 9.00
CHEMBL3922056 — EC50 = 1.0 nM 9.00
CHEMBL3946348 — EC50 = 1.0 nM 9.00
CHEMBL3909834 — EC50 = 1.0 nM 9.00
CHEMBL3907497 — EC50 = 1.0 nM 9.00
CHEMBL3898794 — EC50 = 1.0 nM 9.00
CHEMBL3918046 — EC50 = 1.0 nM 9.00
CHEMBL3915269 — EC50 = 1.0 nM 9.00
CHEMBL3932434 — EC50 = 1.0 nM 9.00
CHEMBL3921499 — EC50 = 1.0 nM 9.00
CHEMBL1923609 — EC50 = 1.0 nM 9.00
CHEMBL1923617 — EC50 = 1.0 nM 9.00
CHEMBL3895776 — EC50 = 1.0 nM 9.00
CHEMBL3893048 — EC50 = 1.0 nM 9.00
CHEMBL1923504 — EC50 = 1.0 nM 9.00
CHEMBL3927481 — EC50 = 1.0 nM 9.00
CHEMBL1923512 — EC50 = 1.0 nM 9.00
CHEMBL3900284 — EC50 = 1.0 nM 9.00
CHEMBL3903845 — EC50 = 1.0 nM 9.00
CHEMBL3910300 — EC50 = 1.0 nM 9.00
CHEMBL3916659 — EC50 = 1.0 nM 9.00
CHEMBL3940705 — EC50 = 1.0 nM 9.00
CHEMBL3943086 — EC50 = 1.0 nM 9.00
CHEMBL3913855 — EC50 = 1.0 nM 9.00
CHEMBL3970499 — EC50 = 1.0 nM 9.00
CHEMBL3913335 — EC50 = 1.0 nM 9.00
CHEMBL3922810 — EC50 = 1.0 nM 9.00
CHEMBL3889512 — EC50 = 1.0 nM 9.00
CHEMBL3959108 — EC50 = 1.0 nM 9.00
CHEMBL3937200 — EC50 = 1.0 nM 9.00
CHEMBL1963249 ULIMORELIN EC50 = 1.0 nM 9.00
CHEMBL3934402 — EC50 = 1.0 nM 9.00
CHEMBL1923638 — EC50 = 1.0 nM 9.00
CHEMBL3938104 — EC50 = 1.0 nM 9.00
CHEMBL3958460 — EC50 = 1.0 nM 9.00
CHEMBL3973085 — EC50 = 1.0 nM 9.00
CHEMBL3898348 — EC50 = 1.0 nM 9.00
CHEMBL1923626 — EC50 = 1.0 nM 9.00
CHEMBL3913052 — EC50 = 1.0 nM 9.00
CHEMBL3905791 — EC50 = 1.0 nM 9.00
CHEMBL3920049 — EC50 = 1.0 nM 9.00
CHEMBL1923612 — EC50 = 16.6 nM 7.78
CHEMBL3905987 — EC50 = 100.0 nM 7.00
CHEMBL3978207 — EC50 = 100.0 nM 7.00
CHEMBL3908264 — EC50 = 100.0 nM 7.00
CHEMBL3896536 — EC50 = 100.0 nM 7.00
CHEMBL1923637 — EC50 = 100.0 nM 7.00
CHEMBL3942642 — EC50 = 100.0 nM 7.00