Assay Detail
Binding
CHEMBL3880445
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Inhibition of aggrecanase in primary porcine chondrocytes assessed as inhibition of 35S-proteoglycan release measured after 9 to 12 hrs by liquid scintillation counting method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Selective inhibitors of aggrecanase in osteoarthritis treatment
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3905996 | — | — | 1 | 8.00 |
| CHEMBL3910163 | — | — | 1 | 8.00 |
| CHEMBL186500 | — | — | 1 | 8.00 |
| CHEMBL3909799 | — | — | 1 | 8.00 |
| CHEMBL3899940 | — | — | 1 | 8.00 |
| CHEMBL363126 | — | — | 1 | 8.00 |
| CHEMBL3968787 | — | — | 1 | 8.00 |
| CHEMBL182306 | — | — | 1 | 8.00 |
| CHEMBL372261 | — | — | 1 | 8.00 |
| CHEMBL3985409 | — | — | 1 | 7.27 |
| CHEMBL179552 | — | — | 1 | - |
| CHEMBL3954431 | — | — | 1 | - |
| CHEMBL3897970 | — | — | 1 | - |
| CHEMBL3895305 | — | — | 1 | - |
| CHEMBL372878 | — | — | 1 | - |
| CHEMBL365283 | — | — | 1 | - |
| CHEMBL3981624 | — | — | 1 | - |
| CHEMBL3979213 | — | — | 1 | - |
| CHEMBL3921667 | — | — | 1 | - |
| CHEMBL187092 | — | — | 1 | - |
| CHEMBL186663 | — | — | 1 | - |
| CHEMBL190415 | — | — | 1 | - |
| CHEMBL3902100 | — | — | 1 | - |
| CHEMBL3955144 | — | — | 1 | - |
| CHEMBL183474 | — | — | 1 | - |
| CHEMBL189216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3905996 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3910163 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL186500 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3909799 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3899940 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL363126 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3968787 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL182306 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL372261 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3985409 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL179552 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3954431 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3897970 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3895305 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL372878 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL365283 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3981624 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3979213 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3921667 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL187092 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL186663 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL190415 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3902100 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3955144 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL183474 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL189216 | — | IC50 | < | 10.0 | nM | - |