Assay Detail
Binding
CHEMBL3880464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-3MeHis-TRH from TRH receptor in Sprague-Dawley rat cortical membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thyrotropin-releasing hormone receptor (CHEMBL4553) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.71 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3897627 | — | — | 1 | 7.65 |
| CHEMBL3954284 | — | — | 1 | 5.15 |
| CHEMBL3906398 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3897627 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL3954284 | — | Ki | = | 7079.46 | nM | 5.15 |
| CHEMBL3906398 | — | Ki | = | 47863.01 | nM | 4.32 |