Assay Detail
Binding
CHEMBL3880756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat brain alpha1B/alpha2b/beta1b N-type calcium channel expressed in HEK293 cells assessed as 0.1 Hz current frequency dependent channel blocking for 2 to 3 mins in presence of Ba2+ by whole-cell patch clamp assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent N-type calcium channel alpha1B/alpha2b/beta1b (CHEMBL3988639) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Calcium channel inhibitors comprising benzhydril spaced from piperazine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.76 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3978555 | — | — | 1 | 7.14 |
| CHEMBL3946261 | — | — | 1 | 6.80 |
| CHEMBL3930176 | — | — | 1 | 6.73 |
| CHEMBL3927466 | — | — | 1 | 6.73 |
| CHEMBL597585 | — | — | 1 | 6.72 |
| CHEMBL3982680 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3978555 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3946261 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3930176 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3927466 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL597585 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3982680 | — | IC50 | = | 359.0 | nM | 6.45 |