Assay Detail
Binding
CHEMBL3880758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at alpha1A/alpha2delta/beta1b P/Q-type calcium channel (unknown origin) expressed in HEK293 cells assessed as 0.1 Hz current frequency dependent channel blocking for 2 to 3 mins in presence of Ba2+ by whole-cell patch clamp assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent P/Q-type calcium channel alpha1A/alpha2delta/beta1b (CHEMBL3988640) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Calcium channel inhibitors comprising benzhydril spaced from piperazine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.40 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597585 | — | — | 1 | 6.01 |
| CHEMBL3982680 | — | — | 1 | 5.47 |
| CHEMBL3946261 | — | — | 1 | 5.35 |
| CHEMBL3978555 | — | — | 1 | 5.30 |
| CHEMBL3930176 | — | — | 1 | 5.12 |
| CHEMBL3927466 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597585 | — | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL3982680 | — | IC50 | = | 3383.0 | nM | 5.47 |
| CHEMBL3946261 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3978555 | — | IC50 | = | 5028.0 | nM | 5.30 |
| CHEMBL3930176 | — | IC50 | = | 7590.0 | nM | 5.12 |
| CHEMBL3927466 | — | IC50 | = | 7592.0 | nM | 5.12 |