Assay Detail

CHEMBL3880786

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Binding

Inverse agonist activity at human histamine H1 receptor by R-SAT assay

ChEMBL ↗

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Target

Histamine H1 receptor (CHEMBL231) ↗

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Primary target Histamine H1 receptor

CHEMBL231

Anchored from Assay target.

Protein identity Histamine H1 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histamine H1 receptor (CHEMBL231) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases

(2004)

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	9.40	9.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL42	CLOZAPINE	4.0	1	9.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL42	CLOZAPINE	EC50	=	0.4	nM	9.40