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Assay Detail

CHEMBL3880925

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC (unknown origin) using Fluor-Lys as substrate
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Isoform Selective HDAC Inhibitors
(2010)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.03 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3943242 1 8.30
CHEMBL468935 1 8.10
CHEMBL511212 1 7.82
CHEMBL387924 1 7.66
CHEMBL227170 1 7.52
CHEMBL3954624 1 7.40
CHEMBL389688 1 7.30
CHEMBL512644 1 7.26
CHEMBL3926370 1 7.10
CHEMBL2417781 1 7.10
CHEMBL98 VORINOSTAT 4.0 1 7.10
CHEMBL389687 1 7.10
CHEMBL3905394 1 7.00
CHEMBL3914588 1 6.70
CHEMBL3966405 1 6.52
CHEMBL3938429 1 5.82
CHEMBL3966183 1 5.52
CHEMBL3947997 1 5.16
CHEMBL3916970 1 -
CHEMBL3919705 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3943242 IC50 = 5.0 nM 8.30
CHEMBL468935 IC50 = 8.0 nM 8.10
CHEMBL511212 IC50 = 15.0 nM 7.82
CHEMBL387924 IC50 = 22.0 nM 7.66
CHEMBL227170 IC50 = 30.0 nM 7.52
CHEMBL3954624 IC50 = 40.0 nM 7.40
CHEMBL389688 IC50 = 50.0 nM 7.30
CHEMBL512644 IC50 = 55.0 nM 7.26
CHEMBL3926370 IC50 = 80.0 nM 7.10
CHEMBL2417781 IC50 = 80.0 nM 7.10
CHEMBL98 VORINOSTAT IC50 = 80.0 nM 7.10
CHEMBL389687 IC50 = 80.0 nM 7.10
CHEMBL3905394 IC50 = 100.0 nM 7.00
CHEMBL3914588 IC50 = 200.0 nM 6.70
CHEMBL3966405 IC50 = 300.0 nM 6.52
CHEMBL3938429 IC50 = 1500.0 nM 5.82
CHEMBL3966183 IC50 = 3000.0 nM 5.52
CHEMBL3947997 IC50 = 7000.0 nM 5.16
CHEMBL3916970 IC50 > 1000.0 nM -
CHEMBL3919705 IC50 > 1000.0 nM -