Assay Detail
Binding
CHEMBL3880976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CatSper1 channel in human sperm assessed as decrease in sperm hyperactivity after 5 mins by computer-assisted sperm analysis
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cation channel sperm-associated protein 1 (CHEMBL1628462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modulators of sperm hypermobility and uses thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 9 | - | - |
| IC50 | 2 | 4.46 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3959118 | — | — | 1 | 4.52 |
| CHEMBL570345 | — | — | 1 | 4.40 |
| CHEMBL3896970 | — | — | 1 | - |
| CHEMBL3917851 | — | — | 1 | - |
| CHEMBL1212966 | — | — | 1 | - |
| CHEMBL3976233 | — | — | 1 | - |
| CHEMBL3899693 | — | — | 1 | - |
| CHEMBL3935008 | — | — | 1 | - |
| CHEMBL3973777 | — | — | 1 | - |
| CHEMBL3914012 | — | — | 1 | - |
| CHEMBL3916771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3959118 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL570345 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3896970 | — | Inhibition | - | % | - | |
| CHEMBL3917851 | — | Inhibition | - | % | - | |
| CHEMBL1212966 | — | Inhibition | - | % | - | |
| CHEMBL3976233 | — | Inhibition | - | % | - | |
| CHEMBL3899693 | — | Inhibition | - | % | - | |
| CHEMBL3935008 | — | Inhibition | - | % | - | |
| CHEMBL3973777 | — | Inhibition | - | % | - | |
| CHEMBL3914012 | — | Inhibition | - | % | - | |
| CHEMBL3916771 | — | Inhibition | - | % | - |