Assay Detail
Binding
CHEMBL3881176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted gamma lactams as therapeutic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.72 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3971632 | — | — | 1 | 9.82 |
| CHEMBL3947001 | — | — | 1 | 9.22 |
| CHEMBL3977724 | — | — | 1 | 8.82 |
| CHEMBL3892847 | — | — | 1 | 8.82 |
| CHEMBL3920756 | — | — | 1 | 8.80 |
| CHEMBL3975238 | — | — | 1 | 8.10 |
| CHEMBL3921784 | — | — | 1 | 8.10 |
| CHEMBL3962183 | — | — | 1 | 7.82 |
| CHEMBL3928130 | — | — | 1 | 7.58 |
| CHEMBL3907809 | — | — | 1 | 7.57 |
| CHEMBL3891401 | — | — | 1 | 7.55 |
| CHEMBL3908484 | — | — | 1 | 7.29 |
| CHEMBL3906402 | — | — | 1 | 6.83 |
| CHEMBL3918349 | — | — | 1 | 6.51 |
| CHEMBL3924987 | — | — | 1 | 6.29 |
| CHEMBL3929446 | — | — | 1 | 6.26 |
| CHEMBL3905811 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3971632 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3947001 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3977724 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3892847 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3920756 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3975238 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3921784 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3962183 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3928130 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3907809 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3891401 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3908484 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3906402 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3918349 | — | EC50 | = | 312.0 | nM | 6.51 |
| CHEMBL3924987 | — | EC50 | = | 517.0 | nM | 6.29 |
| CHEMBL3929446 | — | EC50 | = | 548.0 | nM | 6.26 |
| CHEMBL3905811 | — | EC50 | = | 1218.0 | nM | 5.91 |