Assay Detail
Binding
CHEMBL3881373
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Antagonist activity at TLR1/2 in mouse RAW264.7 cells assessed as inhibition of Pam3CSK4-induced receptor activation by measuring NO production after 24 hrs
28
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antagonists of the toll-like receptor 1/2 complex
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.39 | 6.24 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3935646 | — | — | 2 | 6.24 |
| CHEMBL3985620 | — | — | 1 | 6.14 |
| CHEMBL3968633 | — | — | 1 | 6.00 |
| CHEMBL3914204 | — | — | 1 | 5.90 |
| CHEMBL3973420 | — | — | 1 | 5.87 |
| CHEMBL3940598 | — | — | 1 | 5.87 |
| CHEMBL3950566 | — | — | 1 | 5.85 |
| CHEMBL3964783 | — | — | 1 | 5.65 |
| CHEMBL1485442 | — | — | 1 | 5.63 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 5.61 |
| CHEMBL3953549 | — | — | 1 | 5.61 |
| CHEMBL3937503 | — | — | 1 | 5.55 |
| CHEMBL3932936 | — | — | 1 | 5.55 |
| CHEMBL3915397 | — | — | 1 | 5.51 |
| CHEMBL3966770 | — | — | 1 | 5.50 |
| CHEMBL3911544 | — | — | 1 | 5.49 |
| CHEMBL3909287 | — | — | 1 | 5.39 |
| CHEMBL3966320 | — | — | 1 | 5.32 |
| CHEMBL3916747 | — | — | 1 | 5.32 |
| CHEMBL1556914 | METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE | — | 1 | 5.04 |
| CHEMBL1508229 | — | — | 1 | 4.93 |
| CHEMBL3964988 | — | — | 1 | 4.83 |
| CHEMBL559337 | 7-DESHYDROXYPYROGALLIN-4-CARBOXYLIC ACID | — | 1 | 4.78 |
| CHEMBL3912810 | — | — | 1 | 4.67 |
| CHEMBL3902323 | — | — | 1 | 4.64 |
| CHEMBL134871 | — | — | 1 | 4.40 |
| CHEMBL3966006 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3935646 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3985620 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3968633 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3914204 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3940598 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3973420 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3950566 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3964783 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL1485442 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL3953549 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL3932936 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL3937503 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL3915397 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL3966770 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL3911544 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3909287 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL3916747 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL3966320 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL1556914 | METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL1508229 | — | IC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL3964988 | — | IC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL559337 | 7-DESHYDROXYPYROGALLIN-4-CARBOXYLIC ACID | IC50 | = | 16490.0 | nM | 4.78 |
| CHEMBL3912810 | — | IC50 | = | 21510.0 | nM | 4.67 |
| CHEMBL3902323 | — | IC50 | = | 22740.0 | nM | 4.64 |
| CHEMBL134871 | — | IC50 | = | 39910.0 | nM | 4.40 |
| CHEMBL3966006 | — | IC50 | = | 74580.0 | nM | 4.13 |
| CHEMBL3935646 | — | Inhibition | - | % | - |