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Assay Detail

CHEMBL3881963

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC in human HeLa nuclear extract using Fluor de Lys as substrate after 1 hr by fluorimetric method
ChEMBL ↗
245
Total Activities
245
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Multi-functional small molecules as anti-proliferative agents
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 245 6.71 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL598797 CUDC-101 1.0 1 8.36
CHEMBL598377 — — 1 8.13
CHEMBL98 VORINOSTAT 4.0 1 7.40
CHEMBL3938265 — — 1 7.00
CHEMBL3980019 — — 1 7.00
CHEMBL3947208 — — 1 7.00
CHEMBL3919147 — — 1 7.00
CHEMBL3943406 — — 1 7.00
CHEMBL3980861 — — 1 7.00
CHEMBL3913614 — — 1 7.00
CHEMBL3982861 — — 1 7.00
CHEMBL3980430 — — 1 7.00
CHEMBL3967081 — — 1 7.00
CHEMBL3936512 — — 1 7.00
CHEMBL3946860 — — 1 7.00
CHEMBL3899973 — — 1 7.00
CHEMBL3952020 — — 1 7.00
CHEMBL3951191 — — 1 7.00
CHEMBL2309507 — — 1 7.00
CHEMBL2309506 — — 1 7.00
CHEMBL3946801 — — 1 7.00
CHEMBL3941197 — — 1 7.00
CHEMBL599398 — — 1 7.00
CHEMBL596736 — — 1 7.00
CHEMBL3939206 — — 1 7.00
CHEMBL3898372 — — 1 7.00
CHEMBL3924787 — — 1 7.00
CHEMBL3943805 — — 1 7.00
CHEMBL3905086 — — 1 7.00
CHEMBL3975710 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL598797 CUDC-101 IC50 = 4.4 nM 8.36
CHEMBL598377 — IC50 = 7.4 nM 8.13
CHEMBL98 VORINOSTAT IC50 = 40.0 nM 7.40
CHEMBL3932057 — IC50 = 100.0 nM 7.00
CHEMBL3953980 — IC50 = 100.0 nM 7.00
CHEMBL3968968 — IC50 = 100.0 nM 7.00
CHEMBL3953109 — IC50 = 100.0 nM 7.00
CHEMBL3968380 — IC50 = 100.0 nM 7.00
CHEMBL3917093 — IC50 = 100.0 nM 7.00
CHEMBL3914310 — IC50 = 100.0 nM 7.00
CHEMBL3956995 — IC50 = 100.0 nM 7.00
CHEMBL3954393 — IC50 = 100.0 nM 7.00
CHEMBL3943474 — IC50 = 100.0 nM 7.00
CHEMBL3895707 — IC50 = 100.0 nM 7.00
CHEMBL3907624 — IC50 = 100.0 nM 7.00
CHEMBL3913135 — IC50 = 100.0 nM 7.00
CHEMBL3907592 — IC50 = 100.0 nM 7.00
CHEMBL3942950 — IC50 = 100.0 nM 7.00
CHEMBL3920405 — IC50 = 100.0 nM 7.00
CHEMBL3956162 — IC50 = 100.0 nM 7.00
CHEMBL3906273 — IC50 = 100.0 nM 7.00
CHEMBL3912995 — IC50 = 100.0 nM 7.00
CHEMBL3922737 — IC50 = 100.0 nM 7.00
CHEMBL3957562 — IC50 = 100.0 nM 7.00
CHEMBL3892687 — IC50 = 100.0 nM 7.00
CHEMBL3969644 — IC50 = 100.0 nM 7.00
CHEMBL3938265 — IC50 = 100.0 nM 7.00
CHEMBL3936512 — IC50 = 100.0 nM 7.00
CHEMBL3905131 — IC50 = 100.0 nM 7.00
CHEMBL3967081 — IC50 = 100.0 nM 7.00
CHEMBL3980430 — IC50 = 100.0 nM 7.00
CHEMBL3982861 — IC50 = 100.0 nM 7.00
CHEMBL3913614 — IC50 = 100.0 nM 7.00
CHEMBL3980861 — IC50 = 100.0 nM 7.00
CHEMBL3943406 — IC50 = 100.0 nM 7.00
CHEMBL3919147 — IC50 = 100.0 nM 7.00
CHEMBL3947208 — IC50 = 100.0 nM 7.00
CHEMBL3980019 — IC50 = 100.0 nM 7.00
CHEMBL3929290 — IC50 = 100.0 nM 7.00
CHEMBL3916600 — IC50 = 100.0 nM 7.00
CHEMBL3977186 — IC50 = 100.0 nM 7.00
CHEMBL3899385 — IC50 = 100.0 nM 7.00
CHEMBL3921652 — IC50 = 100.0 nM 7.00
CHEMBL3975710 — IC50 = 100.0 nM 7.00
CHEMBL3936547 — IC50 = 100.0 nM 7.00
CHEMBL3898480 — IC50 = 100.0 nM 7.00
CHEMBL3917105 — IC50 = 100.0 nM 7.00
CHEMBL3917670 — IC50 = 100.0 nM 7.00
CHEMBL3981584 — IC50 = 100.0 nM 7.00
CHEMBL3984055 — IC50 = 100.0 nM 7.00