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Assay Detail

CHEMBL3881965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of N-terminal GST-tagged human HER2 (Lys676 to Val1255 residues) expressed in baculovirus expression system using biotinylated FLT3 at Tyr589 as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA method
ChEMBL ↗
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multi-functional small molecules as anti-proliferative agents
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 6.93 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3899385 — — 1 7.00
CHEMBL3959043 — — 1 7.00
CHEMBL3901236 — — 1 7.00
CHEMBL3901144 — — 1 7.00
CHEMBL597773 — — 1 7.00
CHEMBL597569 — — 1 7.00
CHEMBL604094 — — 1 7.00
CHEMBL598797 CUDC-101 1.0 1 7.00
CHEMBL598164 — — 1 7.00
CHEMBL3898480 — — 1 7.00
CHEMBL605976 — — 1 7.00
CHEMBL3921652 — — 1 7.00
CHEMBL3961102 — — 1 7.00
CHEMBL3951620 — — 1 7.00
CHEMBL3902161 — — 1 7.00
CHEMBL3972249 — — 1 7.00
CHEMBL3977186 — — 1 7.00
CHEMBL3917105 — — 1 7.00
CHEMBL3914322 — — 1 7.00
CHEMBL3938265 — — 1 7.00
CHEMBL3917093 — — 1 7.00
CHEMBL3924346 — — 1 7.00
CHEMBL3981584 — — 1 7.00
CHEMBL3907491 — — 1 7.00
CHEMBL3984055 — — 1 7.00
CHEMBL3952709 — — 1 7.00
CHEMBL3932057 — — 1 7.00
CHEMBL3968968 — — 1 7.00
CHEMBL3950023 — — 1 7.00
CHEMBL3984573 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3959043 — IC50 = 100.0 nM 7.00
CHEMBL605976 — IC50 = 100.0 nM 7.00
CHEMBL3898480 — IC50 = 100.0 nM 7.00
CHEMBL598164 — IC50 = 100.0 nM 7.00
CHEMBL598797 CUDC-101 IC50 = 100.0 nM 7.00
CHEMBL604094 — IC50 = 100.0 nM 7.00
CHEMBL597569 — IC50 = 100.0 nM 7.00
CHEMBL597773 — IC50 = 100.0 nM 7.00
CHEMBL3901144 — IC50 = 100.0 nM 7.00
CHEMBL3901236 — IC50 = 100.0 nM 7.00
CHEMBL3984573 — IC50 = 100.0 nM 7.00
CHEMBL3909900 — IC50 = 100.0 nM 7.00
CHEMBL3898444 — IC50 = 100.0 nM 7.00
CHEMBL596761 — IC50 = 100.0 nM 7.00
CHEMBL3936547 — IC50 = 100.0 nM 7.00
CHEMBL3939306 — IC50 = 100.0 nM 7.00
CHEMBL3905131 — IC50 = 100.0 nM 7.00
CHEMBL598610 — IC50 = 100.0 nM 7.00
CHEMBL598611 — IC50 = 100.0 nM 7.00
CHEMBL3901210 — IC50 = 100.0 nM 7.00
CHEMBL3961102 — IC50 = 100.0 nM 7.00
CHEMBL3972249 — IC50 = 100.0 nM 7.00
CHEMBL3950023 — IC50 = 100.0 nM 7.00
CHEMBL3968968 — IC50 = 100.0 nM 7.00
CHEMBL3932057 — IC50 = 100.0 nM 7.00
CHEMBL3952709 — IC50 = 100.0 nM 7.00
CHEMBL3984055 — IC50 = 100.0 nM 7.00
CHEMBL3907491 — IC50 = 100.0 nM 7.00
CHEMBL3981584 — IC50 = 100.0 nM 7.00
CHEMBL3924346 — IC50 = 100.0 nM 7.00
CHEMBL3938265 — IC50 = 100.0 nM 7.00
CHEMBL3914322 — IC50 = 100.0 nM 7.00
CHEMBL3917105 — IC50 = 100.0 nM 7.00
CHEMBL3977186 — IC50 = 100.0 nM 7.00
CHEMBL3899385 — IC50 = 100.0 nM 7.00
CHEMBL3902161 — IC50 = 100.0 nM 7.00
CHEMBL3951620 — IC50 = 100.0 nM 7.00
CHEMBL3921652 — IC50 = 100.0 nM 7.00
CHEMBL3917093 — IC50 = 100.0 nM 7.00
CHEMBL3967530 — IC50 = 1000.0 nM 6.00
CHEMBL3910297 — IC50 = 1000.0 nM 6.00
CHEMBL3985004 — IC50 = 1000.0 nM 6.00
CHEMBL3929290 — IC50 <= 100.0 nM -
CHEMBL3917670 — IC50 <= 100.0 nM -
CHEMBL3937516 — IC50 <= 100.0 nM -
CHEMBL3971713 — IC50 >= 10000.0 nM -
CHEMBL3968380 — IC50 <= 100.0 nM -
CHEMBL3956995 — IC50 <= 100.0 nM -
CHEMBL3954393 — IC50 <= 100.0 nM -
CHEMBL3928197 — IC50 <= 100.0 nM -