Assay Detail
Binding
CHEMBL3882094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged recombinant human C-Raf Y340D/Y341D double mutant expressed in baculovirus infected Sf21 insect cells using MEK1 as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
RAF serine/threonine protein kinase (CHEMBL3559685) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Multi-functional small molecules as anti-proliferative agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3934468 | — | — | 1 | 6.00 |
| CHEMBL3946124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3934468 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3946124 | — | IC50 | <= | 100.0 | nM | - |