Assay Detail
Functional
CHEMBL3882103
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Antiviral activity against Hepatitis C virus subtype 1b infected in HBI10A cells harboring HCV subgenomic bicistronic replicon assessed as reduction in viral replication
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | HBI10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macrocyclic Quinoxaline Compounds as HCV NS3 Protease Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 8.70 |
| CHEMBL3899923 | — | — | 1 | 8.52 |
| CHEMBL2063089 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3899923 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2063089 | — | EC50 | = | 5.0 | nM | 8.30 |