Assay Detail
Binding
CHEMBL3882216
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Inhibition of rat NHE-2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.85 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | — | 1 | 7.10 |
| CHEMBL465179 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL465179 | — | Ki | = | 250.0 | nM | 6.60 |