Assay Detail
Binding
CHEMBL3882217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit NHE-2
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium/hydrogen exchanger 2 (CHEMBL3770) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.15 | 6.30 |
| IC50 | 1 | 4.10 | 4.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | — | 1 | 6.30 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 6.00 |
| CHEMBL3897683 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL945 | AMILORIDE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3897683 | — | IC50 | = | 80000.0 | nM | 4.10 |