Assay Detail
Binding
CHEMBL3882218
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Inhibition of NHE-2 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.01 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3900457 | — | — | 1 | 7.16 |
| CHEMBL3974005 | — | — | 1 | 6.51 |
| CHEMBL3900790 | — | — | 1 | 6.37 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 5.70 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 5.37 |
| CHEMBL355862 | ZONIPORIDE | 2.0 | 1 | 4.92 |
| CHEMBL51879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3900457 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3974005 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3900790 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL355862 | ZONIPORIDE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL51879 | — | IC50 | = | 1800000.0 | nM | - |