Assay Detail
Binding
CHEMBL3882273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]colchicine binding to bovine brain tubulin incubated at 30 degreeC for 15 mins in presence of GTP by scintillation spectroscopic method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of analogs of the antimitotic marine natural product curacin A
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.02 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89138 | CURACIN A | — | 1 | 6.05 |
| CHEMBL3907122 | — | — | 1 | 5.05 |
| CHEMBL3959071 | — | — | 1 | 5.05 |
| CHEMBL293953 | — | — | 1 | 5.05 |
| CHEMBL3897342 | — | — | 1 | 4.50 |
| CHEMBL432686 | — | — | 1 | 4.41 |
| CHEMBL3921584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89138 | CURACIN A | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3907122 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3959071 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL293953 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3897342 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL432686 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3921584 | — | IC50 | > | 50000.0 | nM | - |