Assay Detail
Binding
CHEMBL3882633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of African green monkey ACAT2 expressed in mouse AC29 cells assessed as reduction in esterification of NBD-cholesterol preincubated for 20 mins followed by NBD-cholesterol addition measured after 6 hrs by high-performance TLC method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Cell Type | AC29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol O-acyltransferase 2 (CHEMBL3879854) ↗| Type | SINGLE PROTEIN |
| Organism | Chlorocebus aethiops |
Publication
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3894947 | — | — | 1 | 6.56 |
| CHEMBL3899908 | — | — | 1 | 6.28 |
| CHEMBL3936899 | — | — | 1 | 6.22 |
| CHEMBL3905226 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3894947 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL3899908 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3936899 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3905226 | — | IC50 | = | 1500.0 | nM | 5.82 |