Assay Detail
Binding
CHEMBL3883063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TCF-4/beta catenin in human Tcf33.13 cells expressing Tcf-4/SV40 binding sites driving firefly luciferase reporter gene after 24 hrs by luminometer
264
Total Activities
264
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Tcf33.13 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Amino-substituted quinazoline derivatives as inhibitors of Beta-catenin/TCF-4 pathway and cancer treatment agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 264 | 6.07 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3934717 | — | — | 1 | 7.09 |
| CHEMBL3955823 | — | — | 1 | 7.07 |
| CHEMBL3897759 | — | — | 1 | 6.97 |
| CHEMBL568799 | — | — | 1 | 6.95 |
| CHEMBL3940417 | — | — | 1 | 6.93 |
| CHEMBL3965907 | — | — | 1 | 6.77 |
| CHEMBL3963724 | — | — | 1 | 6.74 |
| CHEMBL3935110 | — | — | 1 | 6.74 |
| CHEMBL3939175 | — | — | 1 | 6.71 |
| CHEMBL3959525 | — | — | 1 | 6.71 |
| CHEMBL3958263 | — | — | 1 | 6.69 |
| CHEMBL3983546 | — | — | 1 | 6.69 |
| CHEMBL565824 | — | — | 1 | 6.67 |
| CHEMBL566677 | — | — | 1 | 6.67 |
| CHEMBL567285 | — | — | 1 | 6.67 |
| CHEMBL3953370 | — | — | 1 | 6.66 |
| CHEMBL3895814 | — | — | 1 | 6.64 |
| CHEMBL3938608 | — | — | 1 | 6.63 |
| CHEMBL570194 | — | — | 1 | 6.62 |
| CHEMBL3931303 | — | — | 1 | 6.61 |
| CHEMBL3930638 | — | — | 1 | 6.60 |
| CHEMBL569230 | — | — | 1 | 6.59 |
| CHEMBL3897769 | — | — | 1 | 6.59 |
| CHEMBL566462 | — | — | 1 | 6.59 |
| CHEMBL577512 | — | — | 1 | 6.57 |
| CHEMBL3978183 | — | — | 1 | 6.54 |
| CHEMBL568800 | — | — | 1 | 6.54 |
| CHEMBL3970869 | — | — | 1 | 6.54 |
| CHEMBL3895823 | — | — | 1 | 6.52 |
| CHEMBL569004 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3934717 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3955823 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3897759 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL568799 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3940417 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3965907 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3963724 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3935110 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3939175 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL3959525 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL3958263 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3983546 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL566677 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL567285 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL565824 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3953370 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL3895814 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL3938608 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL570194 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL3931303 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3930638 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL569230 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL3897769 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL566462 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL577512 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3978183 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL568800 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL3970869 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL3895823 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL583050 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL569004 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3931398 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL3896117 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL3906097 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL3942535 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL3986596 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL568852 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL3982246 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL566888 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL585131 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL569231 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL3981410 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL3941310 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL3924699 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL3939547 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL3961169 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL3923806 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL3927222 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL3897819 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL569077 | — | IC50 | = | 378.0 | nM | 6.42 |