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Assay Detail

CHEMBL3883076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at C-terminal halo-tag fused human ferroportin expressed in MDCK cells assessed as inhibition of hepcidin-induced ferroportin internalization after overnight incubation by Draq5 staining-based fluorescence assay
ChEMBL ↗
250
Total Activities
250
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type MDCK
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Ferroportin (CHEMBL3392948) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel sulfonaminoquinoline Hepcidin antagonists
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 250 5.23 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL272552 — — 1 6.89
CHEMBL3969259 — — 1 6.60
CHEMBL3904075 — — 1 6.60
CHEMBL3896154 — — 1 6.52
CHEMBL3912604 — — 1 6.51
CHEMBL3894587 — — 1 6.50
CHEMBL3959067 — — 1 6.47
CHEMBL3933529 — — 1 6.44
CHEMBL3919322 — — 1 6.42
CHEMBL3966573 — — 1 6.38
CHEMBL3956864 — — 1 6.38
CHEMBL3958839 — — 1 6.38
CHEMBL3930846 — — 1 6.34
CHEMBL3908826 — — 1 6.34
CHEMBL3914817 — — 1 6.26
CHEMBL256061 — — 1 6.23
CHEMBL3965000 — — 1 6.22
CHEMBL3914642 — — 1 6.22
CHEMBL3933701 — — 1 6.21
CHEMBL3976830 — — 1 6.21
CHEMBL3919719 — — 1 6.16
CHEMBL3947100 — — 1 6.14
CHEMBL3927819 — — 1 6.14
CHEMBL3979691 — — 1 6.12
CHEMBL3892473 — — 1 6.11
CHEMBL429599 — — 1 6.11
CHEMBL3897801 — — 1 6.09
CHEMBL3950354 — — 1 6.07
CHEMBL3959566 — — 1 6.06
CHEMBL3909460 — — 1 6.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL272552 — IC50 = 130.0 nM 6.89
CHEMBL3969259 — IC50 = 250.0 nM 6.60
CHEMBL3904075 — IC50 = 250.0 nM 6.60
CHEMBL3896154 — IC50 = 300.0 nM 6.52
CHEMBL3912604 — IC50 = 307.0 nM 6.51
CHEMBL3894587 — IC50 = 320.0 nM 6.50
CHEMBL3959067 — IC50 = 340.0 nM 6.47
CHEMBL3933529 — IC50 = 360.0 nM 6.44
CHEMBL3919322 — IC50 = 380.0 nM 6.42
CHEMBL3958839 — IC50 = 420.0 nM 6.38
CHEMBL3966573 — IC50 = 413.0 nM 6.38
CHEMBL3956864 — IC50 = 419.0 nM 6.38
CHEMBL3908826 — IC50 = 460.0 nM 6.34
CHEMBL3930846 — IC50 = 460.0 nM 6.34
CHEMBL3914817 — IC50 = 550.0 nM 6.26
CHEMBL256061 — IC50 = 585.0 nM 6.23
CHEMBL3965000 — IC50 = 599.0 nM 6.22
CHEMBL3914642 — IC50 = 600.0 nM 6.22
CHEMBL3976830 — IC50 = 620.0 nM 6.21
CHEMBL3933701 — IC50 = 610.0 nM 6.21
CHEMBL3919719 — IC50 = 690.0 nM 6.16
CHEMBL3927819 — IC50 = 720.0 nM 6.14
CHEMBL3947100 — IC50 = 720.0 nM 6.14
CHEMBL3979691 — IC50 = 760.0 nM 6.12
CHEMBL429599 — IC50 = 770.0 nM 6.11
CHEMBL3892473 — IC50 = 780.0 nM 6.11
CHEMBL3897801 — IC50 = 815.0 nM 6.09
CHEMBL3950354 — IC50 = 857.0 nM 6.07
CHEMBL3959566 — IC50 = 873.0 nM 6.06
CHEMBL3909460 — IC50 = 870.0 nM 6.06
CHEMBL3970065 — IC50 = 910.0 nM 6.04
CHEMBL3900875 — IC50 = 920.0 nM 6.04
CHEMBL3930418 — IC50 = 960.0 nM 6.02
CHEMBL3943490 — IC50 = 960.0 nM 6.02
CHEMBL3965273 — IC50 = 979.0 nM 6.01
CHEMBL3950857 — IC50 = 985.0 nM 6.01
CHEMBL3978323 — IC50 = 990.0 nM 6.00
CHEMBL3929388 — IC50 = 1000.0 nM 6.00
CHEMBL3919188 — IC50 = 990.0 nM 6.00
CHEMBL3916835 — IC50 = 988.0 nM 6.00
CHEMBL3961534 — IC50 = 1000.0 nM 6.00
CHEMBL3969674 — IC50 = 989.0 nM 6.00
CHEMBL3935005 — IC50 = 1000.0 nM 6.00
CHEMBL3903239 — IC50 = 1050.0 nM 5.98
CHEMBL3941683 — IC50 = 1070.0 nM 5.97
CHEMBL3911365 — IC50 = 1100.0 nM 5.96
CHEMBL3977127 — IC50 = 1100.0 nM 5.96
CHEMBL3911568 — IC50 = 1090.0 nM 5.96
CHEMBL3937791 — IC50 = 1140.0 nM 5.94
CHEMBL3985021 — IC50 = 1150.0 nM 5.94